Predicted TF binding site motifs and enrichment analyses indicate that age-related methylation change is influenced by developmental processes, while longevity-related DNAm change is associated with innate immunity or tumorigenesis genes, suggesting that bat longevity results from augmented immune response and cancer suppression.ĭNA methylation (DNAm) influences many processes including development 1, gene regulation 2, genomic imprinting 3, X chromosome inactivation 4, transposable element defense 5, and cancer 6. Furthermore, analysis of several bat genomes reveals that hypermethylated age- and longevity-associated sites are disproportionately located in promoter regions of key transcription factors (TF) and enriched for histone and chromatin features associated with transcriptional regulation. Across species, longevity is negatively associated with the rate of DNAm change at age-associated sites. We demonstrate that DNAm accurately predicts chronological age. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. Nature Communications volume 12, Article number: 1615 ( 2021)Įxceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. ![]() ![]() DNA methylation predicts age and provides insight into exceptional longevity of bats
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Those expecting camp, laughs, or ’80s b-movie nostalgia might be turned off by the serious tone of this gritty, bleak, and existential flick, but fans of The Road Warrior, Book of Eli, or La Jetée should absolutely give it a chance. The Australian DVD is probably the best pick of the bunch, and is definitely worth sourcing, especially if you can find the 2-disc set with both the 90-minute cut with the original ending (which may be preferred) and the 104-minute cut. They are an alternate cut with a different ending, and other slight differences. This extends the running time from 90 minutes to 104 minutes, but these longer versions are not uncut. The VHS release is a passable version, but the optimal viewing experience is one of the international DVDs, generally released under the title Salute of the Juggers.Īside from the much improved image quality, select international DVDs have the added benefit of scenes that were eliminated from the North American release. Under no conditions should you subject yourself to the region 1 disc, it’s so atrocious that a 2nd generation tape of its HBO broadcast would be a better choice. Seriously, the DVD transfer is so botched that you may be turned off this hidden gem entirely. One interesting anomaly that potential viewers of Blood of Heroes should take note of: The North American DVD release of this is abysmal to the point of being worse than the VHS release. Survivors used to more urban environments have retreated beneath the surface where a semi-lawful and controlled state has been maintained by aristocratic rulers. ![]() Humanity has simply been scaled down to scavengers, simple farmers, and third world standards of living. There are no ridiculous vehicles, three eyed mutants, or cheesy science fiction techno embellishments. ![]() In fact, one of the strongest points of this film is its plausible depiction of what Western civilization may be like after its nuclear hastened downfall. This no-holds-barred throwdown is believable enough that it retains the “cringe factor” when one jugger breaks another jugger’s leg, or bites an ear off, Mike Tyson style. There’s no weird orange hue to the fake blood, or obvious foam rubber appliances. Excessive brutality is of paramount importance in this violent sport played with a loose set of rules, and unlike most mid-budget movies, this bloodletting is depicted in semi-realistic fashion. The region four DVD release of the film used a quote from Time Out to pitch the show as Post-Apocalyptic Action: In a futuristic world ravaged by. With that (and an aesthetically pleasing design) we'd be happy. We imagine a simple tree with the name and vital dates of one's immediate ancestors. Most of us find our way into family history research with the dream of creating a family tree to frame and/or share with relatives. Know your family's Irish Pedigree? Here's a free family tree template Preparing to interview a relative by phone or in-person? This printable family tree will help you jot down and visualise key names of shared ancestors, their vital dates, and more. Wanting a visual on how all families in a tree are related Įmbarking on a one-place study for a town or village.Įven if your Irish family tree is only a bit of a stump right now, keeping tabs on your research and mapping out your findings (especially name matches yet to be confirmed or disproved) will call for the support of a family tree maker app eventually, and ideally, one that avoids you having to start over. This guide to Irish family tree makers (best suited to Irish Genealogy) has been compiled to help those: ![]() And that's why the visual mapping power and organisation of a family tree application fast becomes an Irish genealogy must-have. To pin one's own ancestor down (by the power of elimination) one faces the painstaking task of collecting the data of all of these families. READ MORE Irish Naming & Baptism Traditions | What is a Parish? It's easy to get overwhelmed searching for a needle in a haystack, especially when the name is a particularly common one.Church records often reveal several cousins (of the same given name and surname) baptising children at the same time with these very same names.Multiple individuals of the same name frequently appear on record in the same parish, sometimes sharing the same townland address.So researching multiple trees in tandem is common in Irish genealogy. To confound matters the Irish custom of naming a child after a grandparent creates a particular conundrum: To overcome these challenges, digging into the records of neighboring cousins for hidden clues is required. With few surviving 19th-century Irish census records, brick walls are common.Any given Irish household or townland can contain various degrees of kinship.Irish families in the 19th and 20th centuries were famously large.Irish family tree building can be particularly complex because: Along the way, we find ourselves gathering a wild assortment of wild goose-chase vines (along with the desire to quickly weed them out). With Irish ancestry research, it's only a matter of time before one discovery leads to many branches, and with any luck some sturdy roots. ![]() a lot. like our confusing signposts and winding boreens – a fun journey, but difficult to navigate. This article will help you explore how modern technology can ease the pain of planning, comparing, and organising your Irish family tree. Talk to anyone who has spent some time researching their Irish ancestry, and they'll all tell you "it grows legs." 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The news that there would be no Premiership or Championship leagues this year was expected. Their arrival may also have been sparked by the British Speedway statement which came through while the Eagles were practising. Obviously Lewi was their focus and he donned his King’s Lynn race suit for them. Lewi Kerr talks to King’s Lynn Speedway boss, Keith Chapman with Tom Brennan looking on. Word of the practice session clearly filtered to the local newspaper, the Lynn News, who despatched a photographer and reporter. Members of the Eastbourne media team buzzed around shooting videos, capturing audio, taking photographs and generally gathering content. Richard Lawson aboard a Yamaha F2 bike with former rider Peter Seaton. The F2 bikes are 450cc and use standard motocross engines which are low maintenance. Seaton brought with him some F2 bikes and Richard gave a couple a test. ![]() Jason Edwards and Drew Kemp, who also have trips to the Czech Republic lined up, were also quickly in action.Īs the session developed Lewi and Richard put in some really hot laps.Įastbourne had also invited a couple of up-and-coming youngsters to participate in the day, Nathan Ablitt and Vinnie Foord, who both in live in Hailsham.Įastbourne Speedway Director Ian Jordan in conv ersation with Colin Pratt.Ĭolin Pratt, the Peterborough promoter who lives near to the King’s Lynn track, was there, as was Peter Seaton who is promoting F2 Speedway as a way for youngsters to get into the sport without the huge costs. Of course, this was just a practice session.įirst out on track was one of Eastbourne’s teenage tornados, Tom Brennan, eager to get some laps in on the big circuit in preparation for his Euro title tilts in the coming weeks. The sun shone, the track glistened and we were ready to go, well I was going to say racing but it wasn’t quite racing. In addition there is what is termed a “motorway blade” available for major surgery. ![]() Some of the tractors are ancient Zetors, once imported into the UK through the port of King’s Lynn, but others are modern monsters that would not be out of place on any farm. It is fair to say that the Adrian Flux Arena has more tractors and associated kit than some agricultural contractors. A few turns round with the water cart followed. Keith and his team team whizzed round and round to grade the surface which eventually became smooth and looked like a speedway track. It looked like a ploughed field but from long experience I knew that this was a tried and tested method of stadium boss and King’s Lynn Stars supremo, Keith Chapman. Writer Paul Watson was back on his old stomping ground when covering the Eagles’ practice day at King’s Lynn
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