Predicted TF binding site motifs and enrichment analyses indicate that age-related methylation change is influenced by developmental processes, while longevity-related DNAm change is associated with innate immunity or tumorigenesis genes, suggesting that bat longevity results from augmented immune response and cancer suppression.ĭNA methylation (DNAm) influences many processes including development 1, gene regulation 2, genomic imprinting 3, X chromosome inactivation 4, transposable element defense 5, and cancer 6. Furthermore, analysis of several bat genomes reveals that hypermethylated age- and longevity-associated sites are disproportionately located in promoter regions of key transcription factors (TF) and enriched for histone and chromatin features associated with transcriptional regulation. Across species, longevity is negatively associated with the rate of DNAm change at age-associated sites. We demonstrate that DNAm accurately predicts chronological age. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. Nature Communications volume 12, Article number: 1615 ( 2021)Įxceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. ![]() ![]() DNA methylation predicts age and provides insight into exceptional longevity of bats
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